Tesamorelin

Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH). It stimulates the pituitary gland to increase endogenous pulsatile growth hormone (GH) release, leading to downstream increases in IGF-1. Unlike direct HGH administration, Tesamorelin preserves natural feedback mechanisms and physiologic secretion patterns.

It has been clinically shown to selectively reduce visceral adipose tissue (VAT) without significantly affecting subcutaneous fat, making it distinct from other GH secretagogues.